Controlled Delivery of Apomorphine Through Buccal Mucosa, Towards a Noninvasive Administration Method in Parkinson's Disease: A Preclinical Mechanistic Study.

Itin, Constantin; Komargodski, Rinat; Domb, Abraham J; Hoffman, Amnon

Itin, Constantin; Komargodski, Rinat; Domb, Abraham J; Hoffman, Amnon.

Afiliação

Itin C; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel.
Komargodski R; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel.
Domb AJ; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel.
Hoffman A; Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel. Electronic address: amnonh@ekmd.huji.ac.il.

J Pharm Sci ; 109(9): 2729-2734, 2020 09.

Article em En | MEDLINE | ID: mdl-32497595

Assuntos

Mucosa Bucal; Doença de Parkinson; Administração Bucal; Animais; Apomorfina; Humanos; Doença de Parkinson/tratamento farmacológico; Permeabilidade; Suínos

Palavras-chave

Apomorphine; Buccal; Buccal delivery; Controlled delivery; Lipid nanoparticles; Paracellular transport; Permeation enhancer; Transcellular transport; Ussing diffusion chamber; pH

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Mucosa Bucal Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Revista: J Pharm Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Israel País de publicação: Estados Unidos

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