Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10.

Michielon, Elisabetta; López González, Marta; Burm, Judith L A; Waaijman, Taco; Jordanova, Ekaterina S; de Gruijl, Tanja D; Gibbs, Susan

Michielon, Elisabetta; López González, Marta; Burm, Judith L A; Waaijman, Taco; Jordanova, Ekaterina S; de Gruijl, Tanja D; Gibbs, Susan.

Afiliação

Michielon E; Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
López González M; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands.
Burm JLA; Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Waaijman T; Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
Jordanova ES; Center for Gynecologic Oncology Amsterdam (CGOA), Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.
de Gruijl TD; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit, Cancer Center Amsterdam, Amsterdam Infection & Immunity Institute, Amsterdam, The Netherlands.
Gibbs S; Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands. s.gibbs@amsterdamumc.nl.

Cancer Immunol Immunother ; 69(11): 2319-2331, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32507967

Assuntos

Diferenciação Celular/imunologia; Interleucina-10/imunologia; Macrófagos/imunologia; Melanoma/imunologia; Neoplasias Cutâneas/imunologia; Evasão Tumoral/imunologia; Linhagem Celular Tumoral; Humanos; Monócitos/imunologia; Técnicas de Cultura de Órgãos/métodos; Pele; Microambiente Tumoral/imunologia; Melanoma Maligno Cutâneo

Palavras-chave

IL-10; M2 macrophages; Melanoma; Reconstructed human skin; Tumor microenvironment; Tumor progression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Diferenciação Celular / Interleucina-10 / Evasão Tumoral / Macrófagos / Melanoma Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Holanda País de publicação: Alemanha

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