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ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.
Wu, Josephine J; Cai, Ashley; Greenslade, Jessie E; Higgins, Nicole R; Fan, Cong; Le, Nhat T T; Tatman, Micaela; Whiteley, Alexandra M; Prado, Miguel A; Dieriks, Birger V; Curtis, Maurice A; Shaw, Christopher E; Siddique, Teepu; Faull, Richard L M; Scotter, Emma L; Finley, Daniel; Monteiro, Mervyn J.
Afiliação
  • Wu JJ; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Cai A; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Greenslade JE; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Higgins NR; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Fan C; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Le NTT; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Tatman M; Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201.
  • Whiteley AM; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Prado MA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115.
  • Dieriks BV; Department of Anatomy and Medical Imaging, University of Auckland, 1010 Auckland, New Zealand.
  • Curtis MA; Centre for Brain Research, University of Auckland, 1010 Auckland, New Zealand.
  • Shaw CE; Department of Anatomy and Medical Imaging, University of Auckland, 1010 Auckland, New Zealand.
  • Siddique T; Centre for Brain Research, University of Auckland, 1010 Auckland, New Zealand.
  • Faull RLM; United Kingdom Dementia Research Institute, King's College London, WC2R 2LS London, United Kingdom.
  • Scotter EL; Maurice Wohl Clinical Neuroscience Institute, King's College London, SE5 9RT London, United Kingdom.
  • Finley D; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, WC2R 2LS London, United Kingdom.
  • Monteiro MJ; Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
Proc Natl Acad Sci U S A ; 117(26): 15230-15241, 2020 06 30.
Article em En | MEDLINE | ID: mdl-32513711
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Demência / Proteínas Adaptadoras de Transdução de Sinal / Autofagossomos / Proteínas Relacionadas à Autofagia / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Demência / Proteínas Adaptadoras de Transdução de Sinal / Autofagossomos / Proteínas Relacionadas à Autofagia / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos