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Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders.
Delaby, C; Alcolea, D; Carmona-Iragui, M; Illán-Gala, I; Morenas-Rodríguez, E; Barroeta, I; Altuna, M; Estellés, T; Santos-Santos, M; Turon-Sans, J; Muñoz, L; Ribosa-Nogué, R; Sala-Matavera, I; Sánchez-Saudinos, B; Subirana, A; Videla, L; Benejam, B; Sirisi, S; Lehmann, S; Belbin, O; Clarimon, J; Blesa, R; Pagonabarraga, J; Rojas-Garcia, R; Fortea, J; Lleó, A.
Afiliação
  • Delaby C; Université de Montpellier, CHU de Montpellier, Laboratoire de Biochimie-Protéomique clinique, INSERM U1183, Montpellier, France.
  • Alcolea D; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Carmona-Iragui M; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Illán-Gala I; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Morenas-Rodríguez E; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Barroeta I; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Altuna M; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain.
  • Estellés T; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Santos-Santos M; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Turon-Sans J; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Muñoz L; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Ribosa-Nogué R; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Sala-Matavera I; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Sánchez-Saudinos B; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Subirana A; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Videla L; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Benejam B; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Sirisi S; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Lehmann S; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Belbin O; Department of Neurology, Neuromuscular Diseases Unit, MND Clinic, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Clarimon J; Centro de Investigación Biomédica en Red en Enfermedades Raras, Ciberer, Spain.
  • Blesa R; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Pagonabarraga J; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Rojas-Garcia R; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
  • Fortea J; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas, Ciberned, Spain.
  • Lleó A; Department of Neurology, Sant Pau Memory Unit, Hospital de la Santa Creu i Sant Pau - IIB Sant Pau, Barcelona, Spain.
Sci Rep ; 10(1): 9161, 2020 06 08.
Article em En | MEDLINE | ID: mdl-32514050
Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature in various neurodegenerative diseases. In the present study, we analyzed NfL levels in the CSF of 535 participants of the SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We evaluated the differences in CSF NfL accross groups and its association with other CSF biomarkers and with cognitive scales. All neurogenerative diseases showed increased levels of CSF NfL, with the highest levels in patients with ALS, FTD, CBS and PSP. Furthermore, we found an association of CSF NfL levels with cognitive impairment in patients within the AD and FTD spectrum and with AD pathology in DLB and DS patients. These results have implications for the use of NfL as a marker in neurodegenerative diseases.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Neurofilamentos / Doenças Neurodegenerativas Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Neurofilamentos / Doenças Neurodegenerativas Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans / Male Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França País de publicação: Reino Unido