Systematic characterization of the chemical constituents in vitro and prototypes in vivo of Dingkun Dan using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with the UNIFI&#8482; software.

Dou, Xiu-Xiu; Lin, Shan; Tian, Xin-Hui; Zhang, Yu-Hao; Guo, Xin; Ye, Ji; Zhang, Wei-Dong

Systematic characterization of the chemical constituents in vitro and prototypes in vivo of Dingkun Dan using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry combined with the UNIFI™ software.

Dou, Xiu-Xiu; Lin, Shan; Tian, Xin-Hui; Zhang, Yu-Hao; Guo, Xin; Ye, Ji; Zhang, Wei-Dong.

Afiliação

Dou XX; Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lin S; State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai, Shanghai, China.
Tian XH; Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhang YH; Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Guo X; Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ye J; Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, China.
Zhang WD; Interdisciplinary Science Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Biomed Chromatogr ; 34(10): e4914, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32515056

Assuntos

Cromatografia Líquida de Alta Pressão/métodos; Medicamentos de Ervas Chinesas/análise; Medicamentos de Ervas Chinesas/química; Espectrometria de Massas/métodos; Administração Oral; Alcaloides/análise; Animais; Medicamentos de Ervas Chinesas/administração & dosagem; Feminino; Flavonoides/análise; Medicina Tradicional Chinesa; Ratos; Ratos Sprague-Dawley; Saponinas/análise; Triterpenos/análise

Palavras-chave

DKD; TCM; fragmentation pattern; prototype components; ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Espectrometria de Massas / Medicamentos de Ervas Chinesas / Cromatografia Líquida de Alta Pressão Tipo de estudo: Diagnostic_studies / Guideline Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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