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Subacute Oral Administration of Clinacanthus nutans Ethanolic Leaf Extract Induced Liver and Kidney Toxicities in ICR Mice.
Aliyu, Abdullahi; Shaari, Mohd Rosly; Ahmad Sayuti, Nurul Syahirah; Reduan, Mohd Farhan Hanif; Sithambaram, Shanmugavelu; Noordin, Mustapha Mohamed; Shaari, Khozirah; Hamzah, Hazilawati.
Afiliação
  • Aliyu A; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
  • Shaari MR; Department of Veterinary Pathology, Faculty of Veterinary Medicine, City Campus Complex, Usmanu Danfodiyo University, Sokoto 840212, Sokoto State, Nigeria.
  • Ahmad Sayuti NS; Animal Science Research Centre, Malaysian Agricultural Research and Development Institute Headquarter, Serdang 43400, Selangor, Malaysia.
  • Reduan MFH; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
  • Sithambaram S; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
  • Noordin MM; Animal Science Research Centre, Malaysian Agricultural Research and Development Institute Headquarter, Serdang 43400, Selangor, Malaysia.
  • Shaari K; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
  • Hamzah H; Department of Chemistry, Faculty of Science and Environmental Studies, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Molecules ; 25(11)2020 Jun 05.
Article em En | MEDLINE | ID: mdl-32517000
This study investigated the leaves of Clinacanthus nutans for its bioactive compounds and acute and subacute toxicity effects of C. nutans ethanolic leaf extract (CELE) on blood, liver and kidneys of ICR mice. A total of 10 8-week-old female mice were divided into groups A (control) and B (2000 mg/kg) for the acute toxicity study. A single dose of 2000 mg/kg was administered to group B through oral gavage and mice were monitored for 14 days. In the subacute toxicity study, mice were divided into five groups: A (control), B (125 mg/kg), C (250 mg/kg), D (500 mg/kg) and E (1000 mg/kg). The extract was administered daily for 28 days via oral gavage. The mice were sacrificed, and samples were collected for analyses. Myricetin, orientin, isoorientin, vitexin, isovitexin, isookanin, apigenin and ferulic acid were identified in the extract. Twenty-eight days of continuous oral administration revealed significant increases (p < 0.05) in creatinine, ALT and moderate hepatic and renal necrosis in groups D and E. The study concluded that the lethal dose (LD50) of CELE in mice is greater than 2000 mg/kg and that repeated oral administrations of CELE for 28 days induced hepatic and renal toxicities at 1000 mg/kg in female ICR mice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Testes de Toxicidade Aguda / Acanthaceae / Doença Hepática Induzida por Substâncias e Drogas / Rim Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Malásia País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Folhas de Planta / Testes de Toxicidade Aguda / Acanthaceae / Doença Hepática Induzida por Substâncias e Drogas / Rim Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Malásia País de publicação: Suíça