A/G, albumin/globulin ratio; ADRs, adverse drug reactions; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; AUC, the area under the time­plasma concentration curve; BUN, blood urea nitrogen; CL/F, clearance/bioavailability; CR, reatinine; CRISPR, clustered regularly interspaced short palindromic repeats; CRISPR/Cas9; Chr, chromosome; Cmax, peak concentration; DAB, 3,3'-diaminobenzidine; DBL, direct bilirubin; DDI, drug­drug interaction; DMSO, dimethyl sulfoxide; FDA, the U.S. Food and Drug Administration; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GLB, globulin; GLU, glucose; HCG, human chorionic gonadotropin; HDL-C, high density lipoprotein cholesterol; HE, haemotoxylin and eosin; HMG, hydroxymethylglutaryl; HRP, horseradish peroxidase; HZ, heterozygous; IBIL, indirect bilirubin; IS, internal standard solution; KO, knockout; LDL-C, low density lipoprotein cholesterol; MC, methylcellulose; MRT, mean residence time; NC, nitrocellulose; OATP1B1/3; OATP1B1/3, organic anion transporting polypeptide 1B1 and 1B3; OATP1B2; OATPs, organic anion transporting polypeptides; PAM, protospacer adjacent motif; PMSG, pregnant mare serum gonadotropin; R-GT, γ-glutamyltranspeptidase; Rat model; SD, Sprague­Dawley; SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis; SLC, solute carrier; SNPs, single nucleotide polymorphisms; T-CH, total cholesterol; T7E I, T7 endonuclease I; TALEN, transcription activator-like effector nuclease; TBA, total bile acid; TBL, total bilirubin; TBST, Tris-buffered saline Tween 20; TG, triglyceride; TP, total protein; Tmax, peak time; Transporter; UA, uric acid; Ugt1a1, UDP glucuronosyltransferase family 1 member A1; Vd/F, the apparent volume of distribution/bioavailability; WT, wild type; ZFN, zinc-finger nucleases; crRNA, mature CRISPR RNA; p.o., peroral; sgRNA, single guide RNA