[Expression Level of FLRG in Colon Cancer Tissue and Its Clinical Significance].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 51(3): 361-364, 2020 May.
Article
em Zh
| MEDLINE
| ID: mdl-32543143
ABSTRACT
OBJECTIVE:
To investigate the expression of follistatin related gene ( FLRG) in colon cancer and its relationship with clinicopathological features of colon cancer.METHODS:
The cancer tissue, paracancerous tissue and normal tissue were collected from 80 patients with colon cancer who underwent radical operation from December 2018 to December 2019. Immunohistochemistry and Real-time PCR were carried out to examine the expression of FLRG and the clinical implications of FLRG was further analyzed.RESULTS:
The expression of FLRG in colon cancer tissues was significantly higher than that in paracancerous tissues and normal tissues ( P<0.05), and the expression of FLRG in paracancerous tissues was significantly higher than that in normal tissues ( P<0.05). There was no significant difference in the expression of FLRG among colon cancer patients with different sex, age, tumor growth location and differentiation degree ( P>0.05). The expression level of FLRG in patients with distant metastasis was higher than that in patients without distant metastasis ( P<0.05), and the expression level of FLRG in patients with late clinical stage (stage â ¢ and â £) was higher than that in patients with earlier clinical stage (stage â and â ¡) ( P<0.05).CONCLUSION:
FLRG is up-regulated in colon cancer tissue, which may be involved in the regulation of tumor development. FLRG may be a potential prognostic target.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo
/
Proteínas Relacionadas à Folistatina
Limite:
Humans
Idioma:
Zh
Revista:
Sichuan Da Xue Xue Bao Yi Xue Ban
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China