SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus.

Ling, Alexanda K; Munro, Meagan; Chaudhary, Natasha; Li, Conglei; Berru, Maribel; Wu, Brendan; Durocher, Daniel; Martin, Alberto

Ling, Alexanda K; Munro, Meagan; Chaudhary, Natasha; Li, Conglei; Berru, Maribel; Wu, Brendan; Durocher, Daniel; Martin, Alberto.

Afiliação

Ling AK; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Munro M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Chaudhary N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Li C; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Berru M; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Wu B; Department of Immunology, University of Toronto, Toronto, ON, Canada.
Durocher D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Martin A; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.

EMBO Rep ; 21(8): e49823, 2020 08 05.

Article em En | MEDLINE | ID: mdl-32558186

Assuntos

Quebras de DNA de Cadeia Dupla; Switching de Imunoglobulina; Animais; Switching de Imunoglobulina/genética; Camundongos

Palavras-chave

B cell; BRCA1; Shld2−/− mouse; class switch recombination; shieldin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Switching de Imunoglobulina / Quebras de DNA de Cadeia Dupla Limite: Animals Idioma: En Revista: EMBO Rep Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido

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