Differential sensitivity of human neurons carrying µ opioid receptor (MOR) N40D variants in response to ethanol.

Scarnati, Matthew S; Boreland, Andrew J; Joel, Marisa; Hart, Ronald P; Pang, Zhiping P

Scarnati, Matthew S; Boreland, Andrew J; Joel, Marisa; Hart, Ronald P; Pang, Zhiping P.

Afiliação

Scarnati MS; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA.
Boreland AJ; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA.
Joel M; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA.
Hart RP; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, 08854, USA; Human Genetics Institute of New Jersey, Piscataway, NJ, 08854, USA.
Pang ZP; Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, 08901, USA. Electronic address: Zhiping

Alcohol ; 87: 97-109, 2020 09.

Article em En | MEDLINE | ID: mdl-32561311

Assuntos

Etanol; Neurônios/efeitos dos fármacos; Receptores Opioides mu/genética; Transmissão Sináptica/efeitos dos fármacos; Animais; Células Cultivadas; Etanol/toxicidade; Humanos; Camundongos

Palavras-chave

alcohol use disorder (AUD); human disease modeling; induced neuronal cell (iN); induced pluripotent stem (iPS) cell; mu-opioid receptor (MOR); synaptic transmission

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transmissão Sináptica / Receptores Opioides mu / Etanol / Neurônios Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Alcohol Assunto da revista: TRANSTORNOS RELACIONADOS COM SUBSTANCIAS Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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