Preimplantation Genetic Testing: Where We Are Today.
Int J Mol Sci
; 21(12)2020 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-32575575
ABSTRACT
BACKGROUND:
Preimplantation genetic testing (PGT) is widely used today in in-vitro fertilization (IVF) centers over the world for selecting euploid embryos for transfer and to improve clinical outcomes in terms of embryo implantation, clinical pregnancy, and live birth rates.METHODS:
We report the current knowledge concerning these procedures and the results from different clinical indications in which PGT is commonly applied.RESULTS:
This paper illustrates different molecular techniques used for this purpose and the clinical significance of the different oocyte and embryo stage (polar bodies, cleavage embryo, and blastocyst) at which it is possible to perform sampling biopsies for PGT. Finally, genetic origin and clinical significance of embryo mosaicism are illustrated.CONCLUSIONS:
The preimplantation genetic testing is a valid technique to evaluated embryo euploidy and mosaicism before transfer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Testes Genéticos
/
Diagnóstico Pré-Implantação
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Int J Mol Sci
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Itália