mTOR Overcomes Multiple Metabolic Restrictions to Enable HIV-1 Reverse Transcription and Intracellular Transport.

Taylor, Harry E; Calantone, Nina; Lichon, Drew; Hudson, Hannah; Clerc, Isabelle; Campbell, Edward M; D'Aquila, Richard T

Taylor, Harry E; Calantone, Nina; Lichon, Drew; Hudson, Hannah; Clerc, Isabelle; Campbell, Edward M; D'Aquila, Richard T.

Afiliação

Taylor HE; Department of Microbiology and Immunology, State University of New York (SUNY) Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: taylorha@upstate.edu.
Calantone N; Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Lichon D; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
Hudson H; Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Clerc I; Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Campbell EM; Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA.
D'Aquila RT; Division of Infectious Diseases and HIV Translational Research Center, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: richard.daquila@northwestern.edu.

Cell Rep ; 31(12): 107810, 2020 06 23.

Article em En | MEDLINE | ID: mdl-32579936

Assuntos

HIV-1/genética; HIV-1/metabolismo; Espaço Intracelular/metabolismo; Transcrição Reversa/genética; Serina-Treonina Quinases TOR/metabolismo; Acetilcoenzima A/metabolismo; Acetilação; Transporte Biológico; Linfócitos T CD4-Positivos/virologia; Citocinas/metabolismo; Retroalimentação Fisiológica; Glicólise; HIV-1/imunologia; HIV-1/fisiologia; Humanos; Lisina/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Alvo Mecanístico do Complexo 2 de Rapamicina/metabolismo; Microtúbulos/metabolismo; Modelos Biológicos; Receptores de Antígenos de Linfócitos T/metabolismo; Tubulina (Proteína)/metabolismo; Replicação Viral/genética

Palavras-chave

CD4 T cells; HIV-1; HIV-1 replication; host-virus interactions; immunometabolism; mTOR; mTORC1; mTORC2; microtubule stabilization; reverse transcription

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: HIV-1 / Espaço Intracelular / Transcrição Reversa / Serina-Treonina Quinases TOR Limite: Humans Idioma: En Revista: Cell Rep Ano de publicação: 2020 Tipo de documento: Article

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