Association of PON1 gene polymorphisms and enzymatic activity with risk of coronary artery disease.
Future Cardiol
; 17(1): 119-126, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32583675
ABSTRACT
Background:
The present case-control study evaluated the association of PON1 gene polymorphisms and enzyme activity in the western Indian population. Materials &methods:
Angiographically proven coronary artery disease (CAD) formed the cases. PON1 polymorphisms (Q192R, L55M) and enzymatic activity (paraoxonase) were assessed.Results:
A total of 502 participants (251 per group) were studied. PON1 Q192R and L55M polymorphisms were not associated with the risk of CAD. Notably, a weak association was observed between Q192R polymorphisms and the risk of CAD. CAD patients had significantly lower PON1 enzymatic activity (U/L) as compared with the controls regardless of the genotype.Conclusion:
Low serum PON1 activity was confirmed to be an independent predictor for the risk of CAD.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Future Cardiol
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia