Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo.

Liu, Ning; Ma, Mingxing; Qu, Na; Wang, Ruizhe; Chen, Hao; Hu, Fangzhu; Gao, Song; Shan, Fengping

Liu, Ning; Ma, Mingxing; Qu, Na; Wang, Ruizhe; Chen, Hao; Hu, Fangzhu; Gao, Song; Shan, Fengping.

Afiliação

Liu N; Department of Immunology, School of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Sh
Ma M; Department of General Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China.
Qu N; Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44, Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China.
Wang R; Department of Gynecology, No. 1 Affiliated Hospital, China Medical University, No. 155, North Nanjing Street, Heping District, Shenyang 110001, Liaoning, China.
Chen H; Department of Immunology, School of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China.
Hu F; Department of Immunology, School of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China.
Gao S; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, No. 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China.
Shan F; Department of Immunology, School of Basic Medical Science, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, Liaoning Province, China. Electronic address: fpshan@cmu.edu.cn.

Int Immunopharmacol ; 86: 106718, 2020 Sep.

Article em En | MEDLINE | ID: mdl-32585612

Assuntos

Antineoplásicos/farmacologia; Naltrexona/farmacologia; Neoplasias do Colo do Útero/tratamento farmacológico; Animais; Antineoplásicos/uso terapêutico; Apoptose/efeitos dos fármacos; Caderinas/metabolismo; Linhagem Celular Tumoral; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Citocinas/sangue; Transição Epitelial-Mesenquimal/efeitos dos fármacos; Feminino; Técnicas de Silenciamento de Genes; Humanos; Ativação de Macrófagos/efeitos dos fármacos; Camundongos Endogâmicos BALB C; Camundongos Nus; Naltrexona/uso terapêutico; Receptores Opioides/biossíntese; Receptores Opioides/efeitos dos fármacos; Receptores Opioides/genética; Fatores de Transcrição da Família Snail/metabolismo; Macrófagos Associados a Tumor/efeitos dos fármacos; Neoplasias do Colo do Útero/patologia; Vimentina/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cervical cancer; Epithelial-mesenchymal transition (EMT); Low-dose naltrexone (LDN); Opioid growth factor receptor (OGFr); Tumor-associated macrophages (TAMs)

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Naltrexona / Antineoplásicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans Idioma: En Revista: Int Immunopharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google