Maackiain Ameliorates 6-Hydroxydopamine and <i>SNCA</i> Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson's Disease in <i>Caenorhabditis elegans</i> and the SH-SY5Y Cell Line.

Tsai, Rong-Tzong; Tsai, Chia-Wen; Liu, Shih-Ping; Gao, Jia-Xin; Kuo, Yun-Hua; Chao, Pei-Min; Hung, Huey-Shan; Shyu, Woei-Cherng; Lin, Shinn-Zong; Fu, Ru-Huei

Maackiain Ameliorates 6-Hydroxydopamine and SNCA Pathologies by Modulating the PINK1/Parkin Pathway in Models of Parkinson's Disease in Caenorhabditis elegans and the SH-SY5Y Cell Line.

Tsai, Rong-Tzong; Tsai, Chia-Wen; Liu, Shih-Ping; Gao, Jia-Xin; Kuo, Yun-Hua; Chao, Pei-Min; Hung, Huey-Shan; Shyu, Woei-Cherng; Lin, Shinn-Zong; Fu, Ru-Huei.

Afiliação

Tsai RT; Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan.
Tsai CW; Department of Nutrition, China Medical University, Taichung 40402, Taiwan.
Liu SP; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Gao JX; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Kuo YH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Chao PM; Department of Nursing, Taipei Veterans General Hospital, Taipei 12217, Taiwan.
Hung HS; Department of Nutrition, China Medical University, Taichung 40402, Taiwan.
Shyu WC; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
Lin SZ; Translational Medicine Research Center, China Medical University Hospital, Taichung 40447, Taiwan.
Fu RH; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.

Int J Mol Sci ; 21(12)2020 Jun 23.

Article em En | MEDLINE | ID: mdl-32585871

Assuntos

Caenorhabditis elegans/efeitos dos fármacos; Neuroblastoma/tratamento farmacológico; Oxidopamina/toxicidade; Doença de Parkinson/tratamento farmacológico; Proteínas Quinases/metabolismo; Pterocarpanos/farmacologia; Ubiquitina-Proteína Ligases/metabolismo; alfa-Sinucleína/toxicidade; Adrenérgicos/toxicidade; Animais; Apoptose; Autofagia; Caenorhabditis elegans/crescimento & desenvolvimento; Modelos Animais de Doenças; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Neuroblastoma/etiologia; Neuroblastoma/patologia; Doença de Parkinson/etiologia; Doença de Parkinson/patologia; Proteínas Quinases/genética; Ubiquitina-Proteína Ligases/genética

Palavras-chave

6-Hydroxydopamine; Caenorhabditis elegans; Parkinson's disease; SH-SY5Y cell; apoptosis; autophagy; maackiain; parkin; proteasome; α-Synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson / Proteínas Quinases / Oxidopamina / Caenorhabditis elegans / Pterocarpanos / Ubiquitina-Proteína Ligases / Alfa-Sinucleína / Neuroblastoma Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Taiwan País de publicação: Suíça

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