Still naïve or primed: Anticoccidial vaccines call for memory.
Exp Parasitol
; 216: 107945, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32615133
ABSTRACT
Despite decades of investigation to clarify protective mechanisms of anticoccidial responses, one crucial field is neglected, that is, protective memory responses in primed birds. Protective memory immunity is critical for host resistance to reinfection and is the basis of modern vaccinology, especially in developing successful subunit vaccines. There are important differences between the immune responses induced by infections and antigens delivered either as killed, recombinant proteins or as live, replicating vector vaccines or as DNA vaccines. Animals immunized with these vaccines may fail to develop protective memory immunity, and is still naïve to Eimeria infection. This may explain why limited success is achieved in developing next-generation anticoccidial vaccines. In this review, we try to decipher the protective memory responses against Eimeria infection, assess immune responses elicited by various anticoccidial vaccine candidates, and propose possible approaches to develop rational vaccines that can induce a protective memory response to chicken coccidiosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças das Aves Domésticas
/
Galinhas
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Vacinas Protozoárias
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Coccidiose
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Eimeria
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Memória Imunológica
Limite:
Animals
Idioma:
En
Revista:
Exp Parasitol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China