Microbiome of the first stool and overweight at age 3 years: A prospective cohort study.
Pediatr Obes
; 15(11): e12680, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32638554
ABSTRACT
BACKGROUND:
Several reports have revealed that the first-pass meconium hosts a diverse microbiome, but its clinical significance is not known.OBJECTIVE:
We designed a prospective population-based cohort study to evaluate whether the meconium microbiome predicts subsequent growth in children.METHODS:
The study comprised 212 consecutive newborns with a meconium sample and a follow-up sample at 1 year of age. Trained nurses measured the children for weight and length using standardized techniques. We used next-generation sequencing of bacterial 16S rRNA gene and machine-learning approach for the analysis.RESULTS:
The children with overweight at 3 years of age differed in their meconium microbiome from those with normal weight, having a higher proportion of Bacteroidetes phylum (29% vs 15%, P = .013). Using the machine-learning approach, the gut microbiome at birth predicted subsequent overweight with area under the curve 0.70 (SD 0.04). A lower proportion of Staphylococcus at birth was associated with greater length/height at 1 year (ß = -.68, P = .029) and 2 years of age (ß = -.74, P = .030).CONCLUSIONS:
The microbiome of the first-pass meconium predicted subsequent overweight at the age of 3 years. The association between the gut microbiome and overweight appears to start already during pregnancy and at birth.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sobrepeso
/
Microbioma Gastrointestinal
/
Mecônio
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Finlândia