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Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.
García-Huerta, Paula; Troncoso-Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas-Olmedo, Marisol; Henríquez, Daniel R; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A; Geddes, Brad J; Lederkremer, Gerardo Z; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S Pablo; Spichiger, Carlos; Richter, Hans G; Court, Felipe A; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M; Wiseman, R Luke; Gonzalez-Billault, Christian; Bergink, Steven; Vidal, Rene L; Hetz, Claudio.
Afiliação
  • García-Huerta P; Faculty of Medicine, Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.
  • Troncoso-Escudero P; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Wu D; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Sector B, Second Floor, Faculty of Medicine, University of Chile, Independencia 1027, P.O. Box 70086, Santiago, Chile.
  • Thiruvalluvan A; Faculty of Medicine, Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.
  • Cisternas-Olmedo M; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Henríquez DR; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, Sector B, Second Floor, Faculty of Medicine, University of Chile, Independencia 1027, P.O. Box 70086, Santiago, Chile.
  • Plate L; Center for Integrative Biology, Faculty of Sciences, University Mayor, Santiago, Chile.
  • Chana-Cuevas P; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Saquel C; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Thielen P; Faculty of Medicine, Biomedical Neuroscience Institute, University of Chile, Santiago, Chile.
  • Longo KA; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Geddes BJ; Center for Integrative Biology, Faculty of Sciences, University Mayor, Santiago, Chile.
  • Lederkremer GZ; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Sharma N; Department of Cell Biology, Faculty of Sciences, University of Chile, Santiago, Chile.
  • Shenkman M; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
  • Naphade S; Faculty of Medical Sciences, University of Santiago de Chile, Santiago, Chile.
  • Sardi SP; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile.
  • Spichiger C; Center for Integrative Biology, Faculty of Sciences, University Mayor, Santiago, Chile.
  • Richter HG; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA, 02115, USA.
  • Court FA; Proteostasis Therapeutics, Cambridge, MA, USA.
  • Tshilenge KT; Proteostasis Therapeutics, Cambridge, MA, USA.
  • Ellerby LM; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Wiseman RL; George Wise Faculty of Life Sciences, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
  • Gonzalez-Billault C; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Bergink S; George Wise Faculty of Life Sciences, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
  • Vidal RL; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
  • Hetz C; George Wise Faculty of Life Sciences, School of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
Acta Neuropathol ; 140(5): 737-764, 2020 11.
Article em En | MEDLINE | ID: mdl-32642868
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like II / Doença de Huntington / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Alemanha
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like II / Doença de Huntington / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Chile País de publicação: Alemanha