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New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam.
Tran, Thanh-Nha; Sichaem, Jirapast; Nguyen, Van-Kieu; Nguyen, Huu-Hung; Cao, Truong-Tam; Nguyen, Thi-Phuong; Vo, Van-Giau; Niamnont, Nakorn; Nguyen, Ngoc-Hong; Duong, Thuc-Huy.
Afiliação
  • Tran TN; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.
  • Sichaem J; Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand.
  • Nguyen VK; Institute of Fundamental and Applied Sciences, Duy Tan University, Ho Chi Minh City, Vietnam.
  • Nguyen HH; Faculty of Natural Sciences, Duy Tan University, Da Nang, Vietnam.
  • Cao TT; Faculty of Technology, Van Lang University, Ho Chi Minh City, Vietnam.
  • Nguyen TP; Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.
  • Vo VG; NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam.
  • Niamnont N; Department of Industrial and Environmental Engineering, Graduate School of Environment, Gachon University, Seongnam, Korea.
  • Nguyen NH; Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
  • Duong TH; Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
Nat Prod Res ; 36(2): 523-530, 2022 Jan.
Article em En | MEDLINE | ID: mdl-32643405
ABSTRACT
Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3α-acetoxy-16ß,17,18-trihydroxyatisane (1) and ent-3α,14,16ß,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17-trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1-5 were evaluated for α-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 µM, respectively. None showed activity in cytotoxicity assay.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Euphorbia / Diterpenos País/Região como assunto: Asia Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Vietnã
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Euphorbia / Diterpenos País/Região como assunto: Asia Idioma: En Revista: Nat Prod Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Vietnã