New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam.
Nat Prod Res
; 36(2): 523-530, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-32643405
ABSTRACT
Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3α-acetoxy-16ß,17,18-trihydroxyatisane (1) and ent-3α,14,16ß,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17-trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1-5 were evaluated for α-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 µM, respectively. None showed activity in cytotoxicity assay.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Euphorbia
/
Diterpenos
País/Região como assunto:
Asia
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Vietnã