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ISKpn40-Mediated Mobilization of the Colistin Resistance Gene mcr-3.11 in Escherichia coli.
He, Yu-Zhang; Long, Teng-Fei; Chen, Cai-Ping; He, Bing; Li, Xing-Ping; Schuyler, Jessica; Chen, Liang; Liao, Xiao-Ping; Liu, Ya-Hong; Sun, Jian.
Afiliação
  • He YZ; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
  • Long TF; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, Guangdong, People's Republic of China.
  • Chen CP; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, People's Republic of China.
  • He B; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
  • Li XP; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, Guangdong, People's Republic of China.
  • Schuyler J; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, People's Republic of China.
  • Chen L; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
  • Liao XP; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, Guangdong, People's Republic of China.
  • Liu YH; Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, People's Republic of China.
  • Sun J; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
Antimicrob Agents Chemother ; 64(10)2020 09 21.
Article em En | MEDLINE | ID: mdl-32660996
ABSTRACT
The mobile colistin resistance gene mcr-3 has globally disseminated since it was first reported in 2017 in Escherichia coliIn vitro mobilization assays in this study demonstrate the functionality of the composite transposon structure ISKpn40-mcr-3.11-dgkA-ISKpn40 in wild-type and recA-E. coli strains. These transpositions generated 4-bp duplications at the target sites. This is the first report demonstrating the mobility of the mcr-3.11 gene by transposition.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Proteínas de Escherichia coli / Farmacorresistência Bacteriana Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colistina / Proteínas de Escherichia coli / Farmacorresistência Bacteriana Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2020 Tipo de documento: Article