Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits.

Sewell, Fiona; Kimber, Ian; Boobis, Alan R

Sewell, Fiona; Kimber, Ian; Boobis, Alan R.

Afiliação

Sewell F; The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London, NW1 2BE, UK. Electronic address: fiona.sewell@nc3rs.org.uk.
Kimber I; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M20 9BX, UK.
Boobis AR; National Heart & Lung Institute, Imperial College London, London, W12 0NN, UK.

Regul Toxicol Pharmacol ; 116: 104734, 2020 10.

Article em En | MEDLINE | ID: mdl-32679052

Palavras-chave

3Rs; Dose selection; Kinetically-derived Maximum Dose (KMD); Limit dose; Maximum Tolerated Dose (MTD); Reduction; Refinement

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Regul Toxicol Pharmacol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Holanda

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