Morphological profiling of tubercle bacilli identifies drug pathways of action.

Smith, Trever C; Pullen, Krista M; Olson, Michaela C; McNellis, Morgan E; Richardson, Ian; Hu, Sophia; Larkins-Ford, Jonah; Wang, Xin; Freundlich, Joel S; Ando, D Michael; Aldridge, Bree B

Smith, Trever C; Pullen, Krista M; Olson, Michaela C; McNellis, Morgan E; Richardson, Ian; Hu, Sophia; Larkins-Ford, Jonah; Wang, Xin; Freundlich, Joel S; Ando, D Michael; Aldridge, Bree B.

Afiliação

Smith TC; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Pullen KM; Center for Integrated Management of Antimicrobial Resistance (CIMAR), Tufts University, Boston, MA 02111.
Olson MC; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
McNellis ME; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Richardson I; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Hu S; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Larkins-Ford J; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Wang X; Roxbury Latin School, West Roxbury, MA 02132.
Freundlich JS; Department of Bioinformatics and Computational Biology, University of Maryland, Baltimore County, Baltimore, MD 21250.
Ando DM; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Aldridge BB; Tufts University School of Graduate Biomedical Sciences, Boston, MA 02111.

Proc Natl Acad Sci U S A ; 117(31): 18744-18753, 2020 08 04.

Article em En | MEDLINE | ID: mdl-32680963

Assuntos

Antituberculosos/farmacologia; Descoberta de Drogas/métodos; Mycobacterium tuberculosis; Software; Parede Celular/efeitos dos fármacos; Diarilquinolinas; Ensaios de Triagem em Larga Escala; Mycobacterium tuberculosis/citologia; Mycobacterium tuberculosis/efeitos dos fármacos; Mycobacterium tuberculosis/metabolismo; Transcriptoma/efeitos dos fármacos

Palavras-chave

cell morphology; drug discovery; high throughput; tuberculosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Software / Descoberta de Drogas / Mycobacterium tuberculosis / Antituberculosos Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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