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Total small vessel disease score and functional outcomes following acute intracerebral hemorrhage.
Kimura, Yoko; Miwa, Kaori; Takasugi, Junji; Oyama, Naoki; Todo, Kenichi; Sakaguchi, Manabu; Mochizuki, Hideki; Sasaki, Tsutomu.
Afiliação
  • Kimura Y; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: yokokimura@neurol.med.osaka-u.ac.jp.
  • Miwa K; Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shinmachi, Suita, Osaka, Japan. Electronic address: miwa@osaka-njm.net.
  • Takasugi J; Department of Stroke Medicine, Japan Community Health care Organization Hoshigaoka Medical Center, Osaka, Japan. Electronic address: takasugi@neurol.med.osaka-u.ac.jp.
  • Oyama N; Department of Stroke Medicine, Kawasaki Medical School, Okayama, Japan. Electronic address: oyama@med.kawasaki-m.ac.jp.
  • Todo K; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: ktodo@neurol.med.osaka-u.ac.jp.
  • Sakaguchi M; Department of Neurology, Osaka General Medical Center, Osaka, Japan. Electronic address: sakaguti@neurol.med.osaka-u.ac.jp.
  • Mochizuki H; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: hmochizuki@neurol.med.osaka-u.ac.jp.
  • Sasaki T; Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. Electronic address: sasaki@neurol.med.osaka-u.ac.jp.
J Stroke Cerebrovasc Dis ; 29(8): 105001, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32689644
BACKGROUND: Individual cerebral small vessel disease (SVD) markers are independent predictors for poor prognosis following intracerebral hemorrhage (ICH), however, the impact of the cumulative SVD burden on outcomes remains unclear. We aimed to investigate the association between the global SVD burden and functional outcomes following ICH. METHODS: We retrospectively evaluated a consecutive cohort of patients with ICH who underwent brain magnetic resonance imaging and magnetic resonance angiography, from a prospective registry. We identified the presence and severity of the SVD markers (cerebral microbleeds, lacunar infarctions, periventricular hyperintensities, and deep white matter hyperintensities) and summed them to obtain the modified total SVD score (0-4). Poor functional outcomes were defined as a modified Rankin Scale score at discharge ≥ 3. A multivariate logistic regression model was used to assess the association between patient outcomes and the SVD score. RESULTS: A total of 144 patients were included (65.0 ± 12.2 years, 67.4% male). The modified total SVD score was potentially associated with poor functional outcomes (odds ratio [OR] 1.72, 95% confidence interval [CI] 0.97-3.03) after adjustment for age, sex, history of stroke, chronic kidney disease, prior use of antithrombotic agents, the National Institutes of Health Stroke Scale score on admission, the non-lobar location of ICH, and hematoma volume on admission. Moreover, among older patients (≥ 65 years), the SVD score was associated with poor outcomes (OR 3.11, 95% CI 1.01-9.55). Among those with supratentorial ICH, the score remained significant (OR 2.06, 95% CI 1.11-3.83). CONCLUSIONS: The modified total SVD score may have predictive value for poor functional outcomes following ICH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiografia Cerebral / Hemorragia Cerebral / Angiografia por Ressonância Magnética / Doenças de Pequenos Vasos Cerebrais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Assunto da revista: ANGIOLOGIA / CEREBRO Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Angiografia Cerebral / Hemorragia Cerebral / Angiografia por Ressonância Magnética / Doenças de Pequenos Vasos Cerebrais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Assunto da revista: ANGIOLOGIA / CEREBRO Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos