Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
Clin Exp Hypertens
; 43(1): 49-55, 2021 Jan 02.
Article
em En
| MEDLINE
| ID: mdl-32706597
ABSTRACT
BACKGROUND:
Lichens are a symbiotic association of a fungus with a green alga or cyanobacterium. They are widely used in traditional medicine as a treatment against skin disorders, diabetes and hypertension. THE AIM OF THE STUDY The goal of this paper was to assess the possible antihypertensive and vasorelaxant capacity of the aqueous extract of a lichen species called Oakmoss or Evernia prunastri (L.). MATERIAL ANDMETHODS:
In the present study, the aqueous extract of Oakmoss was prepared, its antihypertensive activity was examined in N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats, and its vasorelaxant ability was performed in rat isolated thoracic aorta.RESULTS:
The results proved that Oakmoss reduced the systolic, diastolic, mean arterial blood pressure, and heart rate in hypertensive rats but not in normotensive rats. Besides, the data showed that Oakmoss exerts its antihypertensive effect through vasorelaxant ability.CONCLUSION:
The present study presents the favorable action of Oakmoss as an antihypertensive agent.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta Torácica
/
Extratos Vegetais
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Parmeliaceae
/
Hipertensão
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Hypertens
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Marrocos