Rapid and efficient chiral method development for lamivudine and tenofovir disoproxil fumarate fixed dose combination using ultra-high performance supercritical fluid chromatography: A design of experiment approach.

Kurmi, Moolchand; Jayaraman, Karthik; Natarajan, Saravanan; Kumar, Gandhi Santosh; Bhutani, Hemant; Bajpai, Lakshmikant

Kurmi, Moolchand; Jayaraman, Karthik; Natarajan, Saravanan; Kumar, Gandhi Santosh; Bhutani, Hemant; Bajpai, Lakshmikant.

Afiliação

Kurmi M; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Syngene International Limited, Bangalore 560099, India.
Jayaraman K; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Syngene International Limited, Bangalore 560099, India.
Natarajan S; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Syngene International Limited, Bangalore 560099, India.
Kumar GS; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Syngene International Limited, Bangalore 560099, India.
Bhutani H; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Bristol-Myers Squibb, Bangalore 560099, India.
Bajpai L; Analytical Research and Development, Biocon Bristol Myers Squibb Research & Development Centre (BBRC), Syngene International Limited, Bangalore 560099, India. Electronic address: lakshmikant.bajpai@syngeneintl.com.

J Chromatogr A ; 1625: 461257, 2020 Aug 16.

Article em En | MEDLINE | ID: mdl-32709317

Assuntos

Cromatografia com Fluido Supercrítico/métodos; Lamivudina/análise; Tenofovir/análise; Lamivudina/química; Padrões de Referência; Reprodutibilidade dos Testes; Estereoisomerismo; Tenofovir/química

Palavras-chave

Chiral separation; Design of experiment (DoE); Fixed dose combination (FDC); Lamivudine (3TC); Tenofovir disoproxil fumarate (TDF); Ultra-high performance supercritical fluid chromatography (UHPSFC)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lamivudina / Cromatografia com Fluido Supercrítico / Tenofovir Idioma: En Revista: J Chromatogr A Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia País de publicação: Holanda

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