Effects of vasoactive intestinal polypeptide infusions on renal function in patients with liver disease.
Clin Exp Pharmacol Physiol
; 15(6): 491-5, 1988 Jun.
Article
em En
| MEDLINE
| ID: mdl-3271622
ABSTRACT
1. The effect of intravenous vasoactive intestinal peptide (VIP, 6 pmol/kg per min) on renal function in six patients with cirrhosis of the liver was examined. 2. VIP caused generalized vasodilation and increased plasma renin activity, but diminished the glomerular filtration rate by about one third. 3. The excretion of water, sodium, potassium and calcium also fell significantly. 4. These results differ from our findings in normal man in whom VIP diminished water and electrolyte secretion largely by increasing tubular reabsorption. 5. It is concluded that the elevated VIP levels present in patients with severe liver disease may affect renal function, but that the presence of liver disease may affect renal responses to VIP.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Intestinal Vasoativo
/
Rim
/
Hepatopatias
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Reino Unido