Design, Synthesis, Molecular Docking, and Anticancer Evaluation of Pyrazole Linked Pyrazoline Derivatives with Carbothioamide Tail as EGFR Kinase Inhibitors.

Nawaz, Farah; Alam, Ozair; Perwez, Ahmad; Rizvi, Moshahid A; Naim, Mohd Javed; Siddiqui, Nadeem; Firdaus, Jannat Ul; Rahman, Shakilur; Jha, Mukund; Sheikh, Aadil A

Nawaz, Farah; Alam, Ozair; Perwez, Ahmad; Rizvi, Moshahid A; Naim, Mohd Javed; Siddiqui, Nadeem; Firdaus, Jannat Ul; Rahman, Shakilur; Jha, Mukund; Sheikh, Aadil A.

Afiliação

Nawaz F; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Alam O; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Perwez A; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Rizvi MA; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Naim MJ; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Siddiqui N; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Firdaus JU; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Rahman S; Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Jha M; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.
Sheikh AA; Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi-110062, India.

Anticancer Agents Med Chem ; 21(1): 42-60, 2021.

Article em En | MEDLINE | ID: mdl-32718297

Assuntos

Antineoplásicos/síntese química; Antineoplásicos/farmacologia; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/farmacologia; Pirazóis/síntese química; Tioamidas/química; Apoptose/efeitos dos fármacos; Biomarcadores Tumorais/metabolismo; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Receptores ErbB/antagonistas & inibidores; Gefitinibe/farmacologia; Gefitinibe/normas; Humanos; Conformação Molecular; Simulação de Acoplamento Molecular; Terapia de Alvo Molecular; Ligação Proteica; Pirazóis/farmacologia; Relação Estrutura-Atividade

Palavras-chave

Anticancer; EGFR kinase; apoptosis; carbothioamide; molecular docking studies; pyrazoline

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Tioamidas / Inibidores de Proteínas Quinases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia País de publicação: Holanda

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