Design, synthesis, biological evaluation and in silico studies of novel pyrrolo[3,4-d]pyridazinone derivatives withpromising anti-inflammatory and antioxidant activity.

Szczukowski, Lukasz; Redzicka, Aleksandra; Wiatrak, Benita; Krzyzak, Edward; Marciniak, Aleksandra; Gebczak, Katarzyna; Gebarowski, Tomasz; Swiatek, Piotr

Szczukowski, Lukasz; Redzicka, Aleksandra; Wiatrak, Benita; Krzyzak, Edward; Marciniak, Aleksandra; Gebczak, Katarzyna; Gebarowski, Tomasz; Swiatek, Piotr.

Afiliação

Szczukowski L; Department of Chemistry of Drugs, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland. Electronic address: lukasz.szczukowski@umed.wroc.pl.
Redzicka A; Department of Chemistry of Drugs, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Wiatrak B; Department of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Krzyzak E; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556, Wroclaw, Poland.
Marciniak A; Department of Inorganic Chemistry, Wroclaw Medical University, Borowska 211a, 50-556, Wroclaw, Poland.
Gebczak K; Department of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Gebarowski T; Department of Basic Medical Sciences, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.
Swiatek P; Department of Chemistry of Drugs, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

Bioorg Chem ; 102: 104035, 2020 09.

Article em En | MEDLINE | ID: mdl-32721780

Assuntos

Anti-Inflamatórios/uso terapêutico; Antioxidantes/uso terapêutico; Simulação de Acoplamento Molecular/métodos; Piridazinas/uso terapêutico; Anti-Inflamatórios/farmacologia; Antioxidantes/farmacologia; Simulação por Computador; Desenho de Fármacos; Humanos; Estrutura Molecular; Piridazinas/química; Piridazinas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

1,3,4-Oxadiazole-2-thione; Anti-inflammatory agents; Antioxidants; Cyclooxygenase inhibitors; Mannich bases; Molecular docking; Pyridazinone

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridazinas / Simulação de Acoplamento Molecular / Anti-Inflamatórios / Antioxidantes Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google