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Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium.
Fortner, Renée T; Rice, Megan S; Knutsen, Synnove F; Orlich, Michael J; Visvanathan, Kala; Patel, Alpa V; Gaudet, Mia M; Tjønneland, Anne; Kvaskoff, Marina; Kaaks, Rudolf; Trichopolou, Antonia; Pala, Valeria; Onland-Moret, N Charlotte; Gram, Inger T; Amiano, Pilar; Idahl, Annika; Allen, Naomi E; Weiderpass, Elisabete; Poynter, Jenny N; Robien, Kim; Giles, Graham G; Milne, Roger L; Setiawan, Veronica W; Merritt, Melissa A; van den Brandt, Piet A; Zeleniuch-Jacquotte, Anne; Arslan, Alan A; O'Brien, Katie M; Sandler, Dale P; Wolk, Alicja; Håkansson, Niclas; Harris, Holly R; Trabert, Britton; Wentzensen, Nicolas; Tworoger, Shelley S; Schouten, Leo J.
Afiliação
  • Fortner RT; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. r.fortner@dkfz-heidelberg.de lj.schouten@maastrichtuniversity.nl.
  • Rice MS; Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
  • Knutsen SF; School of Public Health, Loma Linda University, Loma Linda, California.
  • Orlich MJ; School of Public Health, Loma Linda University, Loma Linda, California.
  • Visvanathan K; Johns Hopkins Bloomberg School of Public Health and School of Medicine, Baltimore, Maryland.
  • Patel AV; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
  • Gaudet MM; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
  • Tjønneland A; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • Kvaskoff M; Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Kaaks R; CESP, Fac. de médecine-Univ. Paris-Sud, Fac. de médecine-UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.
  • Trichopolou A; Gustave Roussy, Villejuif, France.
  • Pala V; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Onland-Moret NC; Hellenic Health Foundation, Athens, Greece.
  • Gram IT; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
  • Amiano P; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Idahl A; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
  • Allen NE; Public Health División of Gipuzkoa, BioDonostia Research Institute, San-Sebastian-Donostia, Spain.
  • Weiderpass E; CIBER Epidemiología y Salud Pública, Madrid, Spain.
  • Poynter JN; Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden.
  • Robien K; Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
  • Giles GG; International Agency for Research on Cancer, Lyon, France.
  • Milne RL; Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota.
  • Setiawan VW; Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC.
  • Merritt MA; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  • van den Brandt PA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Zeleniuch-Jacquotte A; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
  • Arslan AA; Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  • O'Brien KM; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
  • Sandler DP; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
  • Wolk A; University of Southern California, Los Angeles, California.
  • Håkansson N; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
  • Harris HR; Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands.
  • Trabert B; New York University School of Medicine, New York, New York.
  • Wentzensen N; New York University School of Medicine, New York, New York.
  • Tworoger SS; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina.
  • Schouten LJ; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, North Carolina.
Cancer Epidemiol Biomarkers Prev ; 29(10): 2010-2018, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32732252
ABSTRACT

BACKGROUND:

Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.

METHODS:

We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.

RESULTS:

Most associations did not vary by tumor site (P het ≥ 0.05). Associations between first pregnancy (P het = 0.04), tubal ligation (P het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases.

CONCLUSIONS:

Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. IMPACT Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: Bioquímica / Epidemiologia / Neoplasias Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: MEDLINE Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Cancer Epidemiol Biomarkers Prev Assunto da revista: Bioquímica / Epidemiologia / Neoplasias Ano de publicação: 2020 Tipo de documento: Artigo