A set of six Gene expression biomarkers and their thresholds identify rat liver tumorigens in short-term assays.

Lewis, Robert W; Hill, Thomas; Corton, J Christopher

Lewis, Robert W; Hill, Thomas; Corton, J Christopher.

Afiliação

Lewis RW; Center for Computational Toxicology and Exposure, U.S. EPA, Research Triangle Park, NC, United States. Electronic address: lewis.robert@epa.gov.
Hill T; Center for Computational Toxicology and Exposure, U.S. EPA, Research Triangle Park, NC, United States; Oak Ridge Institute for Science and Education (ORISE) fellow Office of Research and Development, U.S. Environmental Protection Agency (EPA), Research Triangle Park, NC, United States. Electronic address: thomas.Hill@fda.hhs.gov.
Corton JC; Center for Computational Toxicology and Exposure, U.S. EPA, Research Triangle Park, NC, United States. Electronic address: corton.chris@epa.gov.

Toxicology ; 443: 152547, 2020 10.

Article em En | MEDLINE | ID: mdl-32755643

Assuntos

Biomarcadores Tumorais/genética; Carcinógenos/toxicidade; Neoplasias Hepáticas/induzido quimicamente; Neoplasias Hepáticas/genética; Animais; Bioensaio; Expressão Gênica; Masculino; Ratos Sprague-Dawley

Palavras-chave

Adverse outcome pathway; Aryl hydrocarbon receptor; Constitutive activated receptor; Cytotoxicity; Estrogen receptor; Genotoxicity; Key events; Liver cancer; Molecular initiating events; Peroxisome proliferator-activated receptor α; Thresholds; ToxPi; Transcript profiling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinógenos / Biomarcadores Tumorais / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Toxicology Ano de publicação: 2020 Tipo de documento: Article País de publicação: Irlanda

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