Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.

Price, Roger J; Scott, Mary P; Cantrill, Carina; Higgins, Larry G; Moreau, Marjory; Yoon, Miyoung; Clewell, Harvey J; Creek, Moire R; Osimitz, Thomas G; Houston, J Brian; Lake, Brian G

Kinetics of metabolism of deltamethrin and cis- and trans-permethrin in vitro. Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.

Price, Roger J; Scott, Mary P; Cantrill, Carina; Higgins, Larry G; Moreau, Marjory; Yoon, Miyoung; Clewell, Harvey J; Creek, Moire R; Osimitz, Thomas G; Houston, J Brian; Lake, Brian G.

Afiliação

Price RJ; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Scott MP; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.
Cantrill C; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Higgins LG; Concept Life Sciences (formerly CXR Biosciences Ltd.), Dundee, UK.
Moreau M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Yoon M; ScitoVation, LLC, Research Triangle Park, NC, USA.
Clewell HJ; Ramboll, Research Triangle Park, NC, USA.
Creek MR; Moire Creek Toxicology Consulting Services, Lincoln, CA, USA.
Osimitz TG; Science Strategies, LLC, Charlottesville, VA, USA.
Houston JB; Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, UK.
Lake BG; Faculty of Health and Medical Sciences, University of Surrey, Surrey, UK.

Xenobiotica ; 51(1): 40-50, 2021 Jan.

Article em En | MEDLINE | ID: mdl-32757971

Assuntos

Citosol/metabolismo; Fígado/metabolismo; Permetrina/metabolismo; Animais; Carboxilesterase/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Hepatócitos/metabolismo; Humanos; Cinética; Masculino; Microssomos Hepáticos/metabolismo; Nitrilas/metabolismo; Piretrinas/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

Deltamethrin; cis-permethrin; hepatocytes; human; liver cytosol; liver microsomes; nonspecific binding; rat; trans-permethrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Permetrina / Citosol / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Xenobiotica Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido

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