Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in <i>Apoe</i>-deficient mice.

Higashi, Yusuke; Sukhanov, Sergiy; Shai, Shaw-Yung; Danchuk, Svitlana; Snarski, Patricia; Li, Zhaohui; Hou, Xuwei; Hamblin, Milton H; Woods, T Cooper; Wang, Meifang; Wang, Derek; Yu, Hong; Korthuis, Ronald J; Yoshida, Tadashi; Delafontaine, Patrice

Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in Apoe-deficient mice.

Higashi, Yusuke; Sukhanov, Sergiy; Shai, Shaw-Yung; Danchuk, Svitlana; Snarski, Patricia; Li, Zhaohui; Hou, Xuwei; Hamblin, Milton H; Woods, T Cooper; Wang, Meifang; Wang, Derek; Yu, Hong; Korthuis, Ronald J; Yoshida, Tadashi; Delafontaine, Patrice.

Afiliação

Higashi Y; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Sukhanov S; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Shai SY; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Danchuk S; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Snarski P; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Li Z; Department of Radiology, University of Missouri School of Medicine, Columbia, Missouri.
Hou X; Department of Medicine, University of Missouri School of Medicine, Columbia, Missouri.
Hamblin MH; Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana.
Woods TC; Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana.
Wang M; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Wang D; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Yu H; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Korthuis RJ; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri.
Yoshida T; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
Delafontaine P; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.

Am J Physiol Heart Circ Physiol ; 319(4): H730-H743, 2020 10 01.

Article em En | MEDLINE | ID: mdl-32795184

Assuntos

Doenças da Aorta/metabolismo; Aterosclerose/metabolismo; Permeabilidade Capilar; Células Endoteliais/metabolismo; Receptor IGF Tipo 1/deficiência; Animais; Antígenos CD/metabolismo; Doenças da Aorta/genética; Doenças da Aorta/patologia; Aterosclerose/genética; Aterosclerose/patologia; Caderinas/metabolismo; Modelos Animais de Doenças; Progressão da Doença; Células Endoteliais/patologia; Humanos; Camundongos Endogâmicos C57BL; Camundongos Knockout para ApoE; Placa Aterosclerótica; Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo; Receptor IGF Tipo 1/genética; Receptor IGF Tipo 1/metabolismo; Células THP-1; Proteínas de Junções Íntimas/metabolismo; Junções Íntimas/metabolismo

Palavras-chave

IGF; atherosclerosis; endothelium; insulin like; vascular permeability

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças da Aorta / Permeabilidade Capilar / Receptor IGF Tipo 1 / Células Endoteliais / Aterosclerose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Am J Physiol Heart Circ Physiol Assunto da revista: CARDIOLOGIA / FISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

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