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The cholesterol metabolite 27-hydroxycholesterol inhibits SARS-CoV-2 and is markedly decreased in COVID-19 patients.
Marcello, Alessandro; Civra, Andrea; Milan Bonotto, Rafaela; Nascimento Alves, Lais; Rajasekharan, Sreejith; Giacobone, Chiara; Caccia, Claudio; Cavalli, Roberta; Adami, Marco; Brambilla, Paolo; Lembo, David; Poli, Giuseppe; Leoni, Valerio.
Afiliação
  • Marcello A; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, 34149, Italy.
  • Civra A; Laboratory of Molecular Virology and Antiviral Research, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, 10043, Italy.
  • Milan Bonotto R; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, 34149, Italy.
  • Nascimento Alves L; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, 34149, Italy.
  • Rajasekharan S; Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, 34149, Italy.
  • Giacobone C; Laboratory of Clinical Chemistry, Hospitals of Desio and Monza, ASST-Monza and Department of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy.
  • Caccia C; Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.
  • Cavalli R; Department of Drug Science and Technology, University of Turin, Turin, Italy.
  • Adami M; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133, Italy.
  • Brambilla P; Laboratory of Clinical Chemistry, Hospitals of Desio and Monza, ASST-Monza and Department of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy.
  • Lembo D; Laboratory of Molecular Virology and Antiviral Research, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, 10043, Italy. Electronic address: david.lembo@unito.it.
  • Poli G; Unit of General Pathology and Physiopathology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, 10043, Italy. Electronic address: giuseppe.poli@unito.it.
  • Leoni V; Laboratory of Clinical Chemistry, Hospitals of Desio and Monza, ASST-Monza and Department of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy.
Redox Biol ; 36: 101682, 2020 09.
Article em En | MEDLINE | ID: mdl-32810737
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pneumonia Viral / Infecções por Coronavirus / Betacoronavirus / Hidroxicolesteróis Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália País de publicação: Holanda
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pneumonia Viral / Infecções por Coronavirus / Betacoronavirus / Hidroxicolesteróis Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália País de publicação: Holanda