Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing.

Yokouchi, Yuji; Suzuki, Shinichi; Ohtsuki, Noriko; Yamamoto, Kei; Noguchi, Satomi; Soejima, Yumi; Goto, Mizuki; Ishioka, Ken; Nakamura, Izumi; Suzuki, Satoru; Takenoshita, Seiichi; Era, Takumi

Yokouchi, Yuji; Suzuki, Shinichi; Ohtsuki, Noriko; Yamamoto, Kei; Noguchi, Satomi; Soejima, Yumi; Goto, Mizuki; Ishioka, Ken; Nakamura, Izumi; Suzuki, Satoru; Takenoshita, Seiichi; Era, Takumi.

Afiliação

Yokouchi Y; Pluripotent Stem Cell Research Unit in Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan. yokouchy@fmu.ac.jp.
Suzuki S; Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan. yokouchy@fmu.ac.jp.
Ohtsuki N; Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Yamamoto K; Pluripotent Stem Cell Research Unit in Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Noguchi S; Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Soejima Y; Pluripotent Stem Cell Research Unit in Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Goto M; Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Ishioka K; Pluripotent Stem Cell Research Unit in Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Nakamura I; Department of Thyroid and Endocrinology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Suzuki S; Department of Cell Modulation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Takenoshita S; Department of Cell Modulation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto, Japan.
Era T; Department of Dermatology, Faculty of Medicine, Oita University, Yufu, Japan.

Sci Rep ; 10(1): 13927, 2020 08 18.

Article em En | MEDLINE | ID: mdl-32811847

Assuntos

Proteínas de Bactérias/metabolismo; Proteínas Associadas a CRISPR/metabolismo; Endodesoxirribonucleases/metabolismo; Edição de Genes/métodos; Polimorfismo de Nucleotídeo Único/genética; Alelos; Proteínas de Bactérias/genética; Proteínas Associadas a CRISPR/genética; Sistemas CRISPR-Cas/genética; Colágeno Tipo VII/genética; Colágeno Tipo VII/metabolismo; Endodesoxirribonucleases/genética; Endonucleases/genética; Genoma Humano/genética; Humanos; Células-Tronco Pluripotentes Induzidas/fisiologia; Mutação/genética; Nucleotídeos/genética; Células-Tronco Pluripotentes/fisiologia; Proteínas Proto-Oncogênicas c-ret/genética; Proteínas Proto-Oncogênicas c-ret/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Polimorfismo de Nucleotídeo Único / Endodesoxirribonucleases / Proteínas Associadas a CRISPR / Edição de Genes Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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