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An orally available non-nucleotide STING agonist with antitumor activity.
Pan, Bo-Sheng; Perera, Samanthi A; Piesvaux, Jennifer A; Presland, Jeremy P; Schroeder, Gottfried K; Cumming, Jared N; Trotter, B Wesley; Altman, Michael D; Buevich, Alexei V; Cash, Brandon; Cemerski, Saso; Chang, Wonsuk; Chen, Yiping; Dandliker, Peter J; Feng, Guo; Haidle, Andrew; Henderson, Timothy; Jewell, James; Kariv, Ilona; Knemeyer, Ian; Kopinja, Johnny; Lacey, Brian M; Laskey, Jason; Lesburg, Charles A; Liang, Rui; Long, Brian J; Lu, Min; Ma, Yanhong; Minnihan, Ellen C; O'Donnell, Greg; Otte, Ryan; Price, Laura; Rakhilina, Larissa; Sauvagnat, Berengere; Sharma, Sharad; Tyagarajan, Sriram; Woo, Hyun; Wyss, Daniel F; Xu, Serena; Bennett, David Jonathan; Addona, George H.
Afiliação
  • Pan BS; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Perera SA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
  • Piesvaux JA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Presland JP; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Schroeder GK; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
  • Cumming JN; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Trotter BW; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
  • Altman MD; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Buevich AV; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Cash B; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Cemerski S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Chang W; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Chen Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Dandliker PJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Feng G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Haidle A; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Henderson T; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Jewell J; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Kariv I; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Knemeyer I; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Kopinja J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Lacey BM; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Laskey J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Lesburg CA; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Liang R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Long BJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Lu M; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Ma Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Minnihan EC; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • O'Donnell G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Otte R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Price L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Rakhilina L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Sauvagnat B; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Sharma S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Tyagarajan S; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Woo H; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Wyss DF; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Xu S; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA.
  • Bennett DJ; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
  • Addona GH; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
Science ; 369(6506)2020 08 21.
Article em En | MEDLINE | ID: mdl-32820094
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos