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Honeybush Extracts (Cyclopia spp.) Rescue Mitochondrial Functions and Bioenergetics against Oxidative Injury.
Agapouda, Anastasia; Butterweck, Veronika; Hamburger, Matthias; de Beer, Dalene; Joubert, Elizabeth; Eckert, Anne.
Afiliação
  • Agapouda A; University of Basel, Transfaculty Research Platform, Molecular and Cognitive Neuroscience, Neurobiology Lab for Brain Aging and Mental Health, Basel, Switzerland.
  • Butterweck V; Psychiatric University Clinics, Basel, Switzerland.
  • Hamburger M; University of Applied Sciences and Arts Northwestern Switzerland (FHNW), School of Life Sciences, Institute of Pharmaceutical Technology, Gründenstrasse 40, 4132 Muttenz, Switzerland.
  • de Beer D; Division of Pharmaceutical Biology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Joubert E; Plant Bioactives Group, Post-Harvest and Agro-Processing Technologies, Agricultural Research Council (ARC) Infruitec-Nietvoorbij, Private Bag X5026, Stellenbosch 7599, South Africa.
  • Eckert A; Department of Food Science, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, South Africa.
Oxid Med Cell Longev ; 2020: 1948602, 2020.
Article em En | MEDLINE | ID: mdl-32831989
Mitochondrial dysfunction plays a major role not only in the pathogenesis of many oxidative stress or age-related diseases such as neurodegenerative as well as mental disorders but also in normal aging. There is evidence that oxidative stress and mitochondrial dysfunction are the most upstream and common events in the pathomechanisms of neurodegeneration. Cyclopia species are endemic South African plants and some have a long tradition of use as herbal tea, known as honeybush tea. Extracts of the tea are gaining more scientific attention due to their phenolic composition. In the present study, we tested not only the in vitro mitochondria-enhancing properties of honeybush extracts under physiological conditions but also their ameliorative properties under oxidative stress situations. Hot water and ethanolic extracts of C. subternata, C. genistoides, and C. longifolia were investigated. Pretreatment of human neuroblastoma SH-SY5Y cells with honeybush extracts, at a concentration range of 0.1-1 ng/ml, had a beneficial effect on bioenergetics as it increased ATP production, respiration, and mitochondrial membrane potential (MMP) after 24 hours under physiological conditions. The aqueous extracts of C. subternata and C. genistoides, in particular, showed a protective effect by rescuing the bioenergetic and mitochondrial deficits under oxidative stress conditions (400 µM H2O2 for 3 hours). These findings indicate that honeybush extracts could constitute candidates for the prevention of oxidative stress with an impact on aging processes and age-related neurodegenerative disorders potentially leading to the development of a condition-specific nutraceutical.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Estresse Oxidativo / Metabolismo Energético / Mitocôndrias / Antioxidantes Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Extratos Vegetais / Estresse Oxidativo / Metabolismo Energético / Mitocôndrias / Antioxidantes Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos