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Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection.
Elledge, Susanna K; Zhou, Xin X; Byrnes, James R; Martinko, Alexander J; Lui, Irene; Pance, Katarina; Lim, Shion A; Glasgow, Jeff E; Glasgow, Anum A; Turcios, Keirstinne; Iyer, Nikita; Torres, Leonel; Peluso, Michael J; Henrich, Timothy J; Wang, Taia T; Tato, Cristina M; Leung, Kevin K; Greenhouse, Bryan; Wells, James A.
Afiliação
  • Elledge SK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Zhou XX; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Byrnes JR; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Martinko AJ; Soteria Biotherapeutics, San Francisco, California, 94107, USA.
  • Lui I; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Pance K; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Lim SA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Glasgow JE; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Glasgow AA; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
  • Turcios K; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
  • Iyer N; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
  • Torres L; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
  • Peluso MJ; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
  • Henrich TJ; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
  • Wang TT; Chan Zuckerberg Biohub, San Francisco, California, 94158, USA.
  • Tato CM; Departments of Medicine and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, 94305, USA.
  • Leung KK; Chan Zuckerberg Biohub, San Francisco, California, 94158, USA.
  • Greenhouse B; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
  • Wells JA; Department of Medicine, University of California San Francisco, San Francisco, California, 94158, USA.
medRxiv ; 2020 Aug 21.
Article em En | MEDLINE | ID: mdl-32839788
Current serology tests for SARS-CoV-2 antibodies mainly take the form of enzyme-linked immunosorbent assays or lateral flow assays, with the former being laborious and the latter being expensive and often lacking sufficient sensitivity and scalability. Here we present the development and validation of a rapid, low-cost solution-based assay to detect antibodies in serum, plasma, whole blood, and saliva, using rationally designed split luciferase antibody biosensors (spLUC). This new assay, which generates quantitative results in as short as 5 minutes, substantially reduces the complexity and improves the scalability of COVID-19 antibody tests for point-of-care and broad population testing.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: MedRxiv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: MedRxiv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos