The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma.

Liu, Qingqing; Hua, Shixian; Wang, Xinyi; Chen, Feihong; Gou, Shaohua

Liu, Qingqing; Hua, Shixian; Wang, Xinyi; Chen, Feihong; Gou, Shaohua.

Afiliação

Liu Q; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.
Hua S; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Wang X; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.
Chen F; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China.
Gou S; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing, 211189, China.

Cancer Immunol Immunother ; 70(2): 497-508, 2021 Feb.

Article em En | MEDLINE | ID: mdl-32840656

Assuntos

Carcinoma Hepatocelular/tratamento farmacológico; Imunoterapia/métodos; Irinotecano/uso terapêutico; Neoplasias Hepáticas/tratamento farmacológico; Inibidores da Topoisomerase I/uso terapêutico; Animais; Humanos; Irinotecano/farmacologia; Camundongos; Inibidores da Topoisomerase I/farmacologia

Palavras-chave

Anticancer; Chemo-immunotherapy; Hepatocellular carcinoma; Irinotecan; Tryptophan-2,3-dioxygenase (TDO)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Inibidores da Topoisomerase I / Irinotecano / Imunoterapia / Neoplasias Hepáticas Limite: Animals / Humans Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Alemanha

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