Simvastatin-loaded nanoemulsions: development, characterization, stability study and toxicity assays.
Ther Deliv
; 11(8): 497-505, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32842914
ABSTRACT
Aim:
The aim of this study is to prepare and characterize simvastatin-loaded nanoemulsions (SIM-LN) as well as evaluate their physicochemical properties and toxicity. Methodology &results:
The SIM-LN were prepared, their characteristics evaluated for 30 days, and after that, the SIM-LN toxicity was evaluated using Vero cell culture and the in vivo model of Caenorhabditis elegans. The prepared SIM-LN had an average droplet size of 139 ± 22 nm, with high encapsulation rate (>98.4%). The storage at room temperature proved to be the most optimal condition. Toxicity assays demonstrated no toxicity.Conclusion:
It was demonstrated that the surfactants used as emulsifiers optimized the properties without side effects, because no toxicity was measured in preliminary tests.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Ther Deliv
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Brasil