Ketotherapeutics for neurodegenerative diseases.
Int Rev Neurobiol
; 155: 141-168, 2020.
Article
em En
| MEDLINE
| ID: mdl-32854853
Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastest growing neurodegenerative diseases worldwide. The former is primarily characterized by memory loss and the latter by the motor symptoms of tremor and bradykinesia. Both AD and PD are progressive diseases that share several key underlying mitochondrial, inflammatory, and other metabolic pathologies. This review will detail how these pathologies intersect with ketone body metabolism and signaling, and how ketone bodies, particularly d-ß-hydroxybutyrate (ßHB), may serve as a potential adjunctive nutritional therapy for two of the world's most devastating conditions.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Neurodegenerativas
/
Corpos Cetônicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Int Rev Neurobiol
Ano de publicação:
2020
Tipo de documento:
Article
País de publicação:
Estados Unidos