Your browser doesn't support javascript.
loading
2000-year-old pathogen genomes reconstructed from metagenomic analysis of Egyptian mummified individuals.
Neukamm, Judith; Pfrengle, Saskia; Molak, Martyna; Seitz, Alexander; Francken, Michael; Eppenberger, Partick; Avanzi, Charlotte; Reiter, Ella; Urban, Christian; Welte, Beatrix; Stockhammer, Philipp W; Teßmann, Barbara; Herbig, Alexander; Harvati, Katerina; Nieselt, Kay; Krause, Johannes; Schuenemann, Verena J.
Afiliação
  • Neukamm J; Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Pfrengle S; Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Molak M; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Sand 14, 72076, Tübingen, Germany.
  • Seitz A; Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Francken M; Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Eppenberger P; Museum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679, Warsaw, Poland.
  • Avanzi C; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097, Warsaw, Poland.
  • Reiter E; Institute for Bioinformatics and Medical Informatics, University of Tübingen, Sand 14, 72076, Tübingen, Germany.
  • Urban C; Senckenberg Centre for Human Evolution and Paleoenvironments, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Welte B; Paleoanthropology, Dept. of Geosciences, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Stockhammer PW; Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Teßmann B; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, USA.
  • Herbig A; Institute for Archaeological Sciences, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Harvati K; Institute of Evolutionary Medicine, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.
  • Nieselt K; Institute of Pre- and Protohistory and Medieval Archaeology, Department of Early Prehistory and Quaternary Ecology, University of Tübingen, Rümelinstrasse 19-23, 72070, Tübingen, Germany.
  • Krause J; Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig Maximilian University Munich, 80799, Munich, Germany.
  • Schuenemann VJ; Max Planck Institute for the Science of Human History, Kahlaische Str. 10, 07745, Jena, Germany.
BMC Biol ; 18(1): 108, 2020 08 28.
Article em En | MEDLINE | ID: mdl-32859198
ABSTRACT

BACKGROUND:

Recent advances in sequencing have facilitated large-scale analyses of the metagenomic composition of different samples, including the environmental microbiome of air, water, and soil, as well as the microbiome of living humans and other animals. Analyses of the microbiome of ancient human samples may provide insights into human health and disease, as well as pathogen evolution, but the field is still in its very early stages and considered highly challenging.

RESULTS:

The metagenomic and pathogen content of Egyptian mummified individuals from different time periods was investigated via genetic analysis of the microbial composition of various tissues. The analysis of the dental calculus' microbiome identified Red Complex bacteria, which are correlated with periodontal diseases. From bone and soft tissue, genomes of two ancient pathogens, a 2200-year-old Mycobacterium leprae strain and a 2000-year-old human hepatitis B virus, were successfully reconstructed.

CONCLUSIONS:

The results show the reliability of metagenomic studies on Egyptian mummified individuals and the potential to use them as a source for the extraction of ancient pathogen DNA.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Múmias / Genoma Viral / Genoma Bacteriano / Mycobacterium leprae Limite: Humans País/Região como assunto: Africa Idioma: En Revista: BMC Biol Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Hepatite B / Múmias / Genoma Viral / Genoma Bacteriano / Mycobacterium leprae Limite: Humans País/Região como assunto: Africa Idioma: En Revista: BMC Biol Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Suíça