Reengineering biocatalysts: Computational redesign of chondroitinase ABC improves efficacy and stability.

Hettiaratchi, Marian H; O'Meara, Matthew J; O'Meara, Teresa R; Pickering, Andrew J; Letko-Khait, Nitzan; Shoichet, Molly S

Hettiaratchi, Marian H; O'Meara, Matthew J; O'Meara, Teresa R; Pickering, Andrew J; Letko-Khait, Nitzan; Shoichet, Molly S.

Afiliação

Hettiaratchi MH; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada.
O'Meara MJ; Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Ave. #2017, Ann Arbor, MI 48109, USA.
O'Meara TR; Department of Microbiology and Immunology, University of Michigan, 1150 W. Medical Center Dr., Ann Arbor, MI 48109 USA.
Pickering AJ; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada.
Letko-Khait N; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada.
Shoichet MS; Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S 3E5, Canada.

Sci Adv ; 6(34): eabc6378, 2020 08.

Article em En | MEDLINE | ID: mdl-32875119

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Sci Adv Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Canadá País de publicação: Estados Unidos

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