Nontoxic-dose deoxynivalenol aggravates lipopolysaccharides-induced inflammation and tight junction disorder in IPEC-J2 cells through activation of NF-&#954;B and LC3B.

Ge, Lei; Lin, Ziman; Le, Guannan; Hou, Lili; Mao, Xinru; Liu, Shuiping; Liu, Dandan; Gan, Fang; Huang, Kehe

Nontoxic-dose deoxynivalenol aggravates lipopolysaccharides-induced inflammation and tight junction disorder in IPEC-J2 cells through activation of NF-κB and LC3B.

Ge, Lei; Lin, Ziman; Le, Guannan; Hou, Lili; Mao, Xinru; Liu, Shuiping; Liu, Dandan; Gan, Fang; Huang, Kehe.

Afiliação

Ge L; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Lin Z; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Le G; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Hou L; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Mao X; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Liu S; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Liu D; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Gan F; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor
Huang K; College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Institute of Nutritional and Metabolic Disorders in Domestic Animals and Fowls, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; MOE Joint International Research Labor

Food Chem Toxicol ; 145: 111712, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32877744

Assuntos

Inflamação/imunologia; Proteínas Associadas aos Microtúbulos/imunologia; NF-kappa B/imunologia; Junções Íntimas/efeitos dos fármacos; Tricotecenos/toxicidade; Animais; Linhagem Celular; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/imunologia; Inflamação/etiologia; Inflamação/genética; Mucosa Intestinal/efeitos dos fármacos; Mucosa Intestinal/imunologia; Lipopolissacarídeos/efeitos adversos; Proteínas Associadas aos Microtúbulos/genética; NF-kappa B/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/imunologia; Transdução de Sinais/efeitos dos fármacos; Junções Íntimas/imunologia

Palavras-chave

Deoxynivalenol; Inflammation; LC3B; LPS; NF-κB signaling pathway; Tight junction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tricotecenos / NF-kappa B / Junções Íntimas / Inflamação / Proteínas Associadas aos Microtúbulos Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido

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