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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
Lyu, Kun; Zhang, Ye; Zhang, Dongyan; Kahn, Mario; Ter Horst, Kasper W; Rodrigues, Marcos R S; Gaspar, Rafael C; Hirabara, Sandro M; Luukkonen, Panu K; Lee, Seohyuk; Bhanot, Sanjay; Rinehart, Jesse; Blume, Niels; Rasch, Morten Grønbech; Serlie, Mireille J; Bogan, Jonathan S; Cline, Gary W; Samuel, Varman T; Shulman, Gerald I.
Afiliação
  • Lyu K; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.
  • Zhang Y; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Endocrinology & Metabolism, First Hospital of Jilin University, Changchun, Jilin 130021, China.
  • Zhang D; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Kahn M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Ter Horst KW; Department of Endocrinology and Metabolism Amsterdam University Medical Center, 1105AZ Amsterdam, the Netherlands.
  • Rodrigues MRS; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; School of Medicine, State University of Ponta Grossa, Avenida General Carlos Cavalcanti, Ponta Grossa, PR 84030-900, Brazil.
  • Gaspar RC; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Laboratory of Molecular Biology of Exercise, School of Applied Science, University of Campinas, Limeira, SP 13484-350, Brazil.
  • Hirabara SM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Postgraduate Interdisciplinary Program of Health Sciences, Cruzeiro do Sul University, Sao Paulo, SP 01506-000, Brazil.
  • Luukkonen PK; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Lee S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Bhanot S; Ionis Pharmaceuticals, Carlsbad, CA 92008, USA.
  • Rinehart J; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA; Systems Biology Institute, Yale University, West Haven, CT 06516, USA.
  • Blume N; CV Research, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark.
  • Rasch MG; Antibody Technology, Novo Nordisk A/S, Novo Nordisk Park, 2760 Maaloev, Denmark.
  • Serlie MJ; Department of Endocrinology and Metabolism Amsterdam University Medical Center, 1105AZ Amsterdam, the Netherlands.
  • Bogan JS; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cell Biology, Yale School of Medicine, New Haven, CT 06510, USA.
  • Cline GW; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
  • Samuel VT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; VA Connecticut Healthcare System, West Haven, CT 06516, USA.
  • Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: gerald.shulman@yale.edu.
Cell Metab ; 32(4): 654-664.e5, 2020 10 06.
Article em En | MEDLINE | ID: mdl-32882164
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Diglicerídeos / Proteína Quinase C-épsilon / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Diglicerídeos / Proteína Quinase C-épsilon / Fígado Limite: Animals / Humans / Male Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos