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Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo.
Le Reste, Pierre Jean; Pineau, Raphael; Voutetakis, Konstantinos; Samal, Juhi; Jégou, Gwénaële; Lhomond, Stéphanie; Gorman, Adrienne M; Samali, Afshin; Patterson, John B; Zeng, Qingping; Pandit, Abhay; Aubry, Marc; Soriano, Nicolas; Etcheverry, Amandine; Chatziioannou, Aristotelis; Mosser, Jean; Avril, Tony; Chevet, Eric.
Afiliação
  • Le Reste PJ; Inserm U1242, University of Rennes, Rennes, France; Centre de lutte contre le cancer Eugène Marquis, Rennes, France; Rennes Brain Cancer Team (REACT), 35000, Rennes, France; Neurosurgery Dept, University Hospital of Rennes, 35000, Rennes, France.
  • Pineau R; Inserm U1242, University of Rennes, Rennes, France; Centre de lutte contre le cancer Eugène Marquis, Rennes, France; Rennes Brain Cancer Team (REACT), 35000, Rennes, France.
  • Voutetakis K; Institute of Chemical Biology, National Hellenic Research Foundation (N.H.R.F.), Athens, Greece; Department of Biochemistry and Biotechnology, University of Thessaly, Viopolis, 41500, Larissa, Greece.
  • Samal J; CÚRAM, Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland.
  • Jégou G; Inserm U1242, University of Rennes, Rennes, France; Centre de lutte contre le cancer Eugène Marquis, Rennes, France; Rennes Brain Cancer Team (REACT), 35000, Rennes, France.
  • Lhomond S; CÚRAM, Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland; Apoptosis Research Centre, National University Ireland Galway, Galway, Ireland.
  • Gorman AM; CÚRAM, Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland; Apoptosis Research Centre, National University Ireland Galway, Galway, Ireland.
  • Samali A; Apoptosis Research Centre, National University Ireland Galway, Galway, Ireland.
  • Patterson JB; Fosun OrinovePharmaTech Inc., 3537 Old Conejo Road, Suite 104, Newbury Park, CA, 91320, USA.
  • Zeng Q; Fosun OrinovePharmaTech Inc., 3537 Old Conejo Road, Suite 104, Newbury Park, CA, 91320, USA.
  • Pandit A; CÚRAM, Centre for Research in Medical Devices, National University of Ireland, Galway, Ireland.
  • Aubry M; Rennes Brain Cancer Team (REACT), 35000, Rennes, France; University of Rennes, CNRS, IGDR [(Institut de Génétique et développement de Rennes)]-UMR 6290, F-35000, Rennes, France; CHU Rennes, Service de Génétique Moléculaire et Génomique Médicale, Rennes, France.
  • Soriano N; Rennes Brain Cancer Team (REACT), 35000, Rennes, France; University of Rennes, CNRS, IGDR [(Institut de Génétique et développement de Rennes)]-UMR 6290, F-35000, Rennes, France.
  • Etcheverry A; CHU Rennes, Service de Génétique Moléculaire et Génomique Médicale, Rennes, France.
  • Chatziioannou A; Institute of Chemical Biology, National Hellenic Research Foundation (N.H.R.F.), Athens, Greece; e-NIOS PC, Kallithea-Athens, Greece.
  • Mosser J; Rennes Brain Cancer Team (REACT), 35000, Rennes, France; University of Rennes, CNRS, IGDR [(Institut de Génétique et développement de Rennes)]-UMR 6290, F-35000, Rennes, France; CHU Rennes, Service de Génétique Moléculaire et Génomique Médicale, Rennes, France; University of Rennes, Plateforme GEH,
  • Avril T; Inserm U1242, University of Rennes, Rennes, France; Centre de lutte contre le cancer Eugène Marquis, Rennes, France; Rennes Brain Cancer Team (REACT), 35000, Rennes, France.
  • Chevet E; Inserm U1242, University of Rennes, Rennes, France; Centre de lutte contre le cancer Eugène Marquis, Rennes, France; Rennes Brain Cancer Team (REACT), 35000, Rennes, France. Electronic address: eric.chevet@inserm.fr.
Cancer Lett ; 494: 73-83, 2020 12 01.
Article em En | MEDLINE | ID: mdl-32882336
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzopiranos / Neoplasias Encefálicas / Morfolinas / Terapia Combinada / Glioblastoma Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França País de publicação: Irlanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzopiranos / Neoplasias Encefálicas / Morfolinas / Terapia Combinada / Glioblastoma Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França País de publicação: Irlanda