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Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling.
O'Toole, Dylan; Zaeri, Ali Abdullah I; Nicklin, Stuart A; French, Anne T; Loughrey, Christopher M; Martin, Tamara P.
Afiliação
  • O'Toole D; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK.
  • Zaeri AAI; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK.
  • Nicklin SA; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK.
  • French AT; Clinical Sciences Department, Ross University School of Veterinary Medicine, Basseterre, St. Kitts, West Indies, Saint Kitts and Nevis.
  • Loughrey CM; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK. Electronic address: christopher.loughrey@glasgow.ac.uk.
  • Martin TP; British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular & Medical Sciences, University of Glasgow, UK. Electronic address: tamara.martin@glasgow.ac.uk.
Cell Signal ; 76: 109770, 2020 12.
Article em En | MEDLINE | ID: mdl-32891693
Adverse cardiac remodelling clinically manifests as deleterious changes to heart architecture (size, mass and geometry) and function. These changes, which include alterations to ventricular wall thickness, chamber dilation and poor contractility, are important because they progressively drive patients with cardiac disease towards heart failure and are associated with poor prognosis. Cysteine cathepsins contribute to key signalling pathways involved in adverse cardiac remodelling including synthesis and degradation of the cardiac extracellular matrix (ECM), cardiomyocyte hypertrophy, impaired cardiomyocyte contractility and apoptosis. In this review, we highlight the role of cathepsins in these signalling pathways as well as their translational potential as therapeutic targets in cardiac disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catepsinas / Miócitos Cardíacos / Matriz Extracelular / Cardiopatias Limite: Animals / Humans Idioma: En Revista: Cell Signal Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catepsinas / Miócitos Cardíacos / Matriz Extracelular / Cardiopatias Limite: Animals / Humans Idioma: En Revista: Cell Signal Ano de publicação: 2020 Tipo de documento: Article País de publicação: Reino Unido