Detection of Immunoglobulin M and Immunoglobulin G Antibodies Against Orientia tsutsugamushi for Scrub Typhus Diagnosis and Serosurvey in Endemic Regions.
Indian Pediatr
; 57(12): 1131-1134, 2020 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-32893834
ABSTRACT
OBJECTIVE:
To estimate the regional cutoff of optical density (OD) values for immuno-globulin M (IgM) antibodies against Orientia tsutsugamushi in serum and cerebrospinal fluid (CSF) for clinical diagnosis of scrub typhus and immunoglobulin G (IgG) antibodies in serum for sero-epidemiology in Gorakhpur, Uttar Pradesh, India.METHODS:
We used data from a serological investigation of acute encephalitis syndrome patients (n=407) during the 2016 outbreak in Gorakhpur, India to determine the cutoff for OD values for IgM antibodies, and from community-based serosurveys (n=1991) to estimate the cutoff for OD values for IgG antibodies.RESULTS:
We determined regionally relevant cutoff for OD values of 0.76 for IgM antibodies in serum and 0.22 in cerebrospinal fluid for scrub typhus diagnosis. For serosurveys, IgG antibody cutoff was 1.5.CONCLUSION:
We have proposed locally relevant cutoffs for scrub typhus endemic regions, which may be useful for correctly classifying infected population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Orientia tsutsugamushi
/
Tifo por Ácaros
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Indian Pediatr
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Índia