Aspirin restores endothelial function by mitigating 17ß-estradiol-induced &#945;-SMA accumulation and autophagy inhibition via Vps15 scaffold regulation of Beclin-1 phosphorylation.

Wu, Hangyu; Wu, Siyang; Zhu, Yingchao; Cheng, Jiayi; Ye, Shazhou; Xi, Yang; Huang, Qin; Zhang, Yisheng; Bu, Shizhong

Aspirin restores endothelial function by mitigating 17ß-estradiol-induced α-SMA accumulation and autophagy inhibition via Vps15 scaffold regulation of Beclin-1 phosphorylation.

Wu, Hangyu; Wu, Siyang; Zhu, Yingchao; Cheng, Jiayi; Ye, Shazhou; Xi, Yang; Huang, Qin; Zhang, Yisheng; Bu, Shizhong.

Afiliação

Wu H; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
Wu S; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
Zhu Y; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
Cheng J; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
Ye S; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China.
Xi Y; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China. Electronic address: xiyang@nbu.edu.cn.
Huang Q; Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai, China.
Zhang Y; Department of Obstetrics, Ningbo Medical Center Li Huili Hospital, Ningbo, China. Electronic address: bushizhong@nbu.edu.cn.
Bu S; Diabetes Research Center, School of Medicine, Ningbo University, Ningbo, China. Electronic address: doctorzhangys@139.com.

Life Sci ; 259: 118383, 2020 Oct 15.

Article em En | MEDLINE | ID: mdl-32896555

Assuntos

Actinas/metabolismo; Aspirina/farmacologia; Autofagia/efeitos dos fármacos; Endotélio Vascular/efeitos dos fármacos; Estradiol/metabolismo; Proteína VPS15 de Distribuição Vacuolar/metabolismo; Animais; Western Blotting; Células Cultivadas; Endotélio Vascular/ultraestrutura; Feminino; Humanos; Imunoprecipitação; Camundongos; Camundongos Endogâmicos C57BL; Microscopia Eletrônica de Transmissão; Fosforilação/efeitos dos fármacos

Palavras-chave

Aspirin; Autophagy; Endothelial dysfunction; Estrogen-2; Vasodilatation; α-SMA

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Endotélio Vascular / Aspirina / Actinas / Estradiol / Proteína VPS15 de Distribuição Vacuolar Limite: Animals / Female / Humans Idioma: En Revista: Life Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google