Endocrine, paracrine and autocrine control of follicular development.
Horm Metab Res
; 20(4): 193-203, 1988 Apr.
Article
em En
| MEDLINE
| ID: mdl-3294154
Development of a single follicle during the menstrual cycle is under control of hormones stimulating follicular maturation, ovulation and luteogenesis. Several factors intervene locally to prevent other follicles from developing at the same time as dominant follicle. These other follicles remain quiescent or evaluate to atresia. Atresia results from the action of several endocrine, paracrine and autocrine mechanisms which synergistically inhibit aromatase activity. The subsequent lack of estrogens reduces granulosa cell multiplication. The oocyte will not become fertilizable before the preovulatory peak of LH, after the resumption of meiosis and after reaching metaphase of the second meiotic division. Several factors are involved in the inhibition of spontaneous resumption of meiosis: cyclic nucleotides, sex steroids, somatostatin and oocyte maturation inhibitor(s) (OMI). Ovulation is related to breakdown of connective tissue synthesized by granulosa cells under the influence of FSH. Connective tissue lysis is dependent on proteolytic enzymes which are released and activated by FSH, LH and relaxin. A paracrine control could be involved in ovulation: LH induces the production of prostaglandin and relaxin by theca cells which, in turn, stimulate collagenase and proteoglycanase secretion by granulosa cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândulas Endócrinas
/
Folículo Ovariano
Limite:
Female
/
Humans
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Bélgica
País de publicação:
Alemanha