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Effects of Brazilian green propolis extract on planktonic cells and biofilms of multidrug-resistant strains of Klebsiella pneumoniae and Pseudomonas aeruginosa.
Santos, Pâmela Beatriz do Rosário Estevam Dos; Ávila, Damara da Silva; Ramos, Lucas de Paula; Yu, Amanda Romagnoli; Santos, Carlos Eduardo da Rocha; Berretta, Andresa Aparecida; Camargo, Samira Esteves Afonso; Oliveira, Jonatas Rafael de; Oliveira, Luciane Dias de.
Afiliação
  • Santos PBDRED; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.
  • Ávila DDS; Health Sciences Institute, Universidade Paulista (UNIP), São José dos Campos, SP, Brazil.
  • Ramos LP; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.
  • Yu AR; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.
  • Santos CEDR; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.
  • Berretta AA; Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, SP, Brazil.
  • Camargo SEA; Policlin Institute for Teaching and Research, São José dos Campos, SP, Brazil.
  • Oliveira JR; Research and Development Laboratory, Apis Flora Indl. Coml. Ltda, Ribeirão Preto, SP, Brazil.
  • Oliveira LD; Department of Restorative Dental Sciences, University of Florida, College of Dentistry, Gainesville, FL, USA.
Biofouling ; 36(7): 834-845, 2020 08.
Article em En | MEDLINE | ID: mdl-32954805
ABSTRACT
Propolis could represent an alternative therapeutic agent for targeting multidrug-resistant bacteria due to its antimicrobial potential. The effect of Brazilian green propolis (BGP) aqueous extract (AqExt) was evaluated on eight multidrug-resistant clinical strains of Klebsiella pneumoniae and Pseudomonas aeruginosa, as well as on one reference strain for each bacterial species. The minimum bactericidal concentration (MBC) was determined and optimal concentrations were further evaluated in comparison with 0.12% chlorhexidine. The natural extract was chemically characterized by HPLC-DAD analysis. The MBC values ranged between 3.12 and 27.5 mg ml-1. Analysis of bacterial metabolic activity after treatment for 5 min with BGP-AqExt revealed a strong antimicrobial potential, similar to chlorhexidine. The extract comprised several active compounds including quercetin, gallic acid, caffeic and p-coumaric acid, drupani, galangin, and artepillin C. Altogether, the findings suggest that BGP-AqExt is fast and effective against multidrug-resistant strains of K. pneumoniae and P. aeruginosa in planktonic cultures and biofilms.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Pseudomonas aeruginosa / Biofilmes / Antibacterianos País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biofouling Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Própole / Pseudomonas aeruginosa / Biofilmes / Antibacterianos País/Região como assunto: America do sul / Brasil Idioma: En Revista: Biofouling Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil